• icondeanrnd@iul.ac.in, diriirc@iul.ac.in



The Integral Referral Laboratory for Chemical Analysis and Research (IRL-CAR) stands as a state-of-the-art scientific facility, dedicated to conducting rigorous research and precise analyses across an array of critical areas. Our expertise extends to the examination of metals, pesticides, metabolites, contaminants, polycyclic aromatic hydrocarbons, proteins, vitamins, essential oils, toxic chemicals, and more, across a diverse range of samples. At the heart of IRL-CAR are cutting-edge instruments, including ICP-MS, MDS, LC-MS/MS, X-ray Diffractometer (XRD), High-Performance Liquid Chromatography (HPLC), and high-end UVVIS spectrophotometers, facilitating quantitative analysis of the highest caliber.

IRL-CAR is firmly committed to offering analytical services to a wide spectrum of stakeholders, including researchers and students from universities, academic institutions, medical establishments, national and international research institutes, as well as industries. Our services provide access to top-quality data, available in both hard copy and electronic formats, with a commitment to excellence in every analysis.

The Agilent 7850 ICP Mass Spectrometer represents an intelligent solution aimed at optimizing time management, allowing your skilled staff to direct their efforts towards tasks that truly add value. This versatile instrument is designed to handle samples containing up to 25% solids, reducing the need for laborious dilution procedures.

Key features of the 7850 ICP-MS include a helium mode collision cell and half-mass correction capabilities, effectively eliminating polyatomic and doubly charged ion interferences. This not only simplifies method development but also minimizes the need for sample re-analysis, streamlining your analytical processes.

The Agilent 7850 ICP-MS comes equipped with a suite of fully developed methods that align with EPA regulations and guidelines, ensuring that your elemental analyses meet stringent standards. These methods encompass comprehensive information on instrument conditions, analyte specifications, internal standards, quality control protocols, and reporting criteria. Selecting the appropriate method empowers the fine-tuning of instrument calibration settings and operational parameters, enhancing precision and accuracy in sample measurements.

The Agilent 7850 ICP-MS offers the following benefits:
Macro and Micro Nutrient Analysis

Capable of delivering accurate results for the analysis of essential nutrients at both macro and micro levels, crucial for various applications.

Toxic Metals Analysis

Enables the detection and quantification of toxic metals, ensuring compliance with safety and regulatory requirements.

Incorporating the Agilent 7850 ICP-MS into your analytical workflow can significantly enhance efficiency and reliability, allowing your team to focus on deriving valuable insights from your analyses.

Introducing the Agilent 6475 Triple Quadrupole LC-MS/MS: the cutting-edge evolution of a time-tested workhorse in the realm of LC-MS/MS technology. This sophisticated triple quadrupole mass spectrometer sets new benchmarks in sensitivity, robustness, and versatility, driven by a host of technological innovations.

Distinguishing features of the 6475 LC/TQ include the superheated Agilent Jet Stream (AJS) ion source, a curved and tapered collision cell, heated hyperbolic quadrupoles, and a high-energy dynode detector system with a range of ± 20 kV. In addition, this instrument boasts intelligent functionalities, including early maintenance feedback, scheduled tune and check-tune routines, and intelligent secondary injection workflows.

Through its advanced hardware and these innovative elements, the 6475 LC/TQ effortlessly achieves the stringent limits of detection required for the analysis of various compounds, including pesticides, veterinary drugs, PFAS, nitrosamines, and other regulated substances. These capabilities, combined with onboard instrument intelligence that is both sophisticated and user-friendly, work in harmony to maximize instrument uptime, maintain peak performance, and proactively anticipate maintenance needs.

The Agilent 6475 Triple Quadrupole LC-MS/MS offers an array of benefits, including:
Pesticide Residue Analysis

Delivering precise results for the analysis of pesticide residues, ensuring compliance with safety and regulatory standards.

Drug Metabolites Analysis

Facilitating the investigation of drug metabolites, a critical aspect of pharmaceutical and pharmacological research.

Non-Volatile Compounds Analysis

Enabling the accurate assessment of nonvolatile compounds, expanding the scope of research applications.

With the Agilent 6475 Triple Quadrupole LC-MS/MS, you gain a powerful tool that not only raises the bar in analytical capabilities but also streamlines your operations through intelligent features and user-friendly interfaces.

X-ray Diffraction Analysis (XRD) stands as a nondestructive marvel, delivering a wealth of insights into the crystallographic structure, chemical composition, and physical attributes of materials. It hinges on the artful interplay of monochromatic X-rays and a crystalline sample, yielding a rich tapestry of information.

X-ray Powder Diffraction (XRD), a swift analytical technique, takes the center stage for crystalline material phase identification, while also shedding light on unit cell dimensions. This method requires the precise preparation of the material, finely grinding and homogenizing it to obtain the average bulk composition.

The Rigaku Miniflex 600-C, an instrument with remarkable capabilities:
Chemical Composition Analysis

With this tool in hand, we can delve into the chemical composition of a range of materials, from cement and fly ash to organic compounds and nano-formulations, unlocking the secrets of their elemental makeup.

Physical Properties and Structural Analysis

The Rigaku Miniflex 600-C excels in unraveling the intricacies of physical properties and structural configurations, enriching our understanding of the materials we explore.

In essence, XRD powered by the Rigaku Miniflex 600-C is a gateway to an expansive realm of material analysis, where the finest details of composition and structure are revealed with precision and efficiency.

Shimadzu provides a range of liquid chromatography systems from HPLC (HighPerformance Liquid Chromatography) to UHPLC, preparative systems, and more. The instrument offers solutions for supercritical fluid chromatography and ion chromatography. Lab Solutions' dedicated software simplifies method development and routine workflows for quantitative and qualitative analysis. Shimadzu’s Shim-packTM columns ensure high-quality analysis data over a variety of applications. The instrument provides a host of user-friendly features for quantitative and qualitative analysis.

Shimadzu PROMINENCE offers
  1. 1. Non-volatile compounds analysis
  2. 2. Pesticide and metabolites analysis

Fourier Transform Infrared (FTIR) spectroscopy, a cornerstone of infrared spectroscopy, revolves around a fundamental principle: as infrared (IR) radiation courses through a sample, some of it gets absorbed. What emerges on the other side, the transmitted radiation is meticulously recorded. These recorded spectra are more than mere data; they hold the power to recognize and distinguish between molecules. The uniqueness of these spectra, akin to a person's DNA or fingerprint, is what sets FTIR apart.

A standout feature of FTIR is its non-destructive nature. It gently interrogates the sample, making it not just sensitive but also remarkably precise. In our Central Instrument Facility (CIF), we house the state-ofthe-art Alpha II model from Bruker, a compact FTIR spectroscope with a multitude of advantages.

The Alpha II FTIR boasts several merits:
  • Space Efficiency: It's designed with space in mind, ensuring it complements your laboratory setup seamlessly
  • Maintenance-Free Operation: Enjoy smooth, worry-free functionality, reducing downtime.
  • Versatility in Any Environment: It adapts to various work settings, enhancing its usability.
  • User-Friendly Interface: Its ease of use allows for seamless operation, even for newcomers.
  • Task Adaptability: Swiftly take on new tasks with ease, adding to its versatility.
  • Low Energy Consumption: A greener approach to spectroscopy.

The applications of the BRUKER ALPHA II span a diverse spectrum, extending from organic synthesis and polymer science to petrochemical engineering, pharmaceutical analysis, nanotechnology, and food quality assessment. It shines in identifying different molecules and functional groups attached to nanoparticles, aids in quality control, quantifies and verifies raw materials, and so much more. In essence, it's a powerful tool with a broad array of uses, from process monitoring to compound identification and component determination in complex mixtures.

The BRUKER ALPHA II offers two core analytical capabilities:
  • Functional Group Analysis: Unravel the intricacies of functional groups within your samples.
  • Stretching Frequency Analysis: Delve into the unique stretching frequencies of various compounds.
A.6.1 Analytical and Research services

We proudly extend a diverse spectrum of analytical research and services, catering to the precise analysis of a broad array of substances such as metals, pesticides, drugs, their metabolites, contaminants, polyaromatic hydrocarbons, essential oils, adulterants, and more. These services are tailored to meet the demands of academic institutions, research entities, industries, and manufacturers.

Our offering encompasses an array of specialized services, including:

  • Qualitative and Quantitative Analysis: Providing both qualitative insights and quantitative measurements, ensuring a comprehensive understanding of the sample's     composition
  • Method Development and Validation: Crafting and validating analytical methodologies to meet specific research objectives and regulatory requirements
  • Elemental Analysis: Expert elemental analysis, crucial in understanding the fundamental composition of various materials.
  • Food and Food-Based Products: In-depth analysis of food items, ensuring compliance with safety and quality standards.
  • Analysis of Water and Soil: Detailed examination of water and soil samples, essential for environmental and agricultural studies.
  • Dairy: Specialized services catering to dairy product analysis, ensuring product quality and safety.
  • Ayurvedic and Natural Products: Analyzing Ayurvedic and natural products, a vital aspect of traditional medicine and wellness industries.
  • Cosmetics: Precise analysis of cosmetic products, ensuring safety and compliance with industry standards.
  • Organic Food: A focus on the analysis of organic food products, certifying their authenticity and quality.
  • Pharmaceuticals: Comprehensively evaluating pharmaceuticals to ensure safety and efficacy.

Our comprehensive analytical and research services span various domains, ensuring that the diverse needs of our clients are met with precision and expertise.

A.6.2 Diagnostic services

Our diagnostic services encompass a wide spectrum of essential analyses, catering to the examination of trace elements, metals, pesticides residues, and other critical toxic metabolites. We offer these services to both OPD and IPD patients, serving the needs of IIMS&R, as well as other esteemed hospitals, medical colleges, and institutions.

Our diagnostic capabilities span across various biological samples, ensuring a comprehensive assessment:

  • Blood Samples: In-depth analysis of blood samples, revealing vital insights into the patient's health.
  • Tissues: Careful examination of tissue samples, aiding in the diagnosis and treatment of various medical conditions.
  • Saliva: Precise testing of saliva samples, a valuable source of information about oral and systemic health
  • Tooth: Comprehensive evaluation of dental samples, offering critical data for oral health assessments.
  • Hair: Thorough analysis of hair samples, which can reveal information about exposure to various elements and substances over time.
  • Nails: Examination of nail samples, often indicative of long-term health trends and exposure to certain compounds.
  • Renal Stones: Analyzing renal stones, shedding light on their composition and aiding in patient care.
  • Gall Bladder Stones: In-depth analysis of gall bladder stones, providing insights into their formation and potential treatments.

Our diagnostic services are driven by a commitment to excellence, ensuring that patients receive accurate and timely information to support their medical care and decision-making.

A.6.3 Certification courses/training/skill development programs

We take pride in offering an array of certification courses, training sessions, and hands-on skill development programs tailored to undergraduate (UG), postgraduate (PG), and doctoral (PhD) students at Integral University and other esteemed institutions. These programs are designed to empower students with expertise in the operation of sophisticated instruments, including ICP-MS, MDS, LC-MS/MS, XRD, HPLC, and molecular techniques such as genomics and tissue culture.

Our comprehensive course modules cover the following critical aspects:

  • Sample Preparation: Equipping students/trainees with the art and science of preparing samples for precise and accurate analysis.
  • Principles and Working of Instruments: Delving into the theoretical foundations and operational intricacies of the sophisticated instruments employed.
  • Handling of Instrumentation: Providing hands-on experience, enabling students to navigate and utilize these complex instruments confidently and expertly.
  • Data Interpretation and Analysis: Equipping students/trainees with the skills to interpret the data generated and derive meaningful insights.
  • Troubleshooting: Preparing students to tackle and resolve challenges and technical issues that may arise during instrumental operation.

Our commitment is to foster a new generation of skilled professionals who can harness the power of advanced instrumentation to drive research, innovation, and excellence in their respective fields.

A.6.4 Grant-in-aid support

We are dedicated to securing crucial grant-in-aid support from a diverse array of government and private funding agencies. This support encompasses a range of vital initiatives, including EMR projects, pilot projects, DST-FIST programs, network projects, and consultancy projects. Our mission is to leverage these resources to fuel innovative research and drive transformative projects, ensuring a brighter future for our institution and the communities we serve.

A.6.5 Guidance and services to Research Scholars/Medical PG students

We extend comprehensive guidance and analytical research services to research scholars and medical postgraduate (PG) students hailing from Integral University, as well as other esteemed academic and research institutions. These services are expertly designed to support their dissertation and thesis work, fostering a collaborative environment for knowledge exchange and growth.

Our offerings are available on a fee basis, ensuring that scholars have access to the essential resources, mentorship, and analytical support required for their research pursuits. Our commitment lies in contributing to the success of these scholars as they embark on their academic journeys and advance the frontiers of knowledge.

A.6.6 Hands-On Practical Sessions

Conducting hands-on practical classes that encompass both demonstration and active participation for various groups, including MBBS students, Junior and Senior Residents, postgraduate (PG) scholars, and doctoral (PhD) students. These sessions are meticulously designed to familiarize participants with the operation and applications of sophisticated instruments, serving both research and clinical purposes, and fostering a deeper understanding of their diagnostic and clinical potential.

A.6.7 Information Dissemination and Consultative Services

Our commitment to knowledge sharing and consultancy extends to providing crucial information and research findings to clinicians at IIMS&R who are engaged in treating cases involving heavy metals, pesticides, methanol, Diquat, Paraquat, Aluminum Phosphide, Zinc Phosphide, Phosphorus, and drug metabolites poisoning. We also offer valuable assistance and consultancy services to a diverse spectrum of stakeholders, including researchers, academicians, and forensic laboratory and investigation agencies.

These services encompass a wide range of areas, including the evaluation, monitoring, elimination, and management of various harmful agents, empowering professionals to make informed decisions and take proactive measures to safeguard public health and well-being.

A.6.8 National and International Collaborations and Memorandums of Understanding (MoUs)

Active engagement in collaboration and the establishment of Memorandums of Understanding (MoUs) with a diverse spectrum of partners, including government bodies such as Pollution Control Boards, FDA (Food and Drug Administration), and FSSAI (Food Safety and Standards Authority of India). Our collaborative efforts extend to scientific non-governmental organizations (NGOs), societies, private organizations, and industries, all with a shared focus on analytical research and development. Through these partnerships, we foster an environment of knowledge exchange and innovation, working collectively towards common goals in research, technology advancement, and the betterment of society at large

A.6.9 Guidance on Key Findings and Research Impact

To proactively share critical research findings and recommendations with government regulatory authorities, organizations, and industries, with the aim of influencing policies related to the use, consumption, and industrial generation of toxic agents. Additionally, to publish our research findings, scientific advancements, and relevant information in biannual newsletters. These actions serve as a vital bridge between research and real-world impact, ensuring that our insights are utilized in shaping policies and practices that promote safety, sustainability, and informed decisionmaking within various sectors.

A.6.10 Accreditation and Global Recognition

Our ongoing pursuit involves seeking accreditation and recognition for the Integral Referral Laboratory for Chemical Analysis and Research (IRL-CAR) from prestigious bodies like NABL (National Accreditation Board for Testing and Calibration Laboratories), ISO (International Organization for Standardization), and other esteemed international standards agencies. This commitment to accreditation aligns with our dedication to upholding the highest standards of quality and precision, ensuring that our laboratory operations are benchmarked against the most rigorous international criteria. Such accreditation and recognition are a testament to our unwavering commitment to excellence and credibility in the field of chemical analysis and research.